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Tag: carbohydrates

08.07.2014

carbs fuel colon cancer in mice

Carbohydrate rich diets, especially refined carbohydrates, have been linked to higher rates of colon cancer in the developed world, when compared to developing nations. A new report in the journal Cell,  provides insight into how this might come to be. Science News explains:

To probe the link between colon tumors and gut microbes, the researchers treated mice engineered to be prone to colon cancer with antibiotics. By eradicating intestinal bacteria, the drugs hindered malignant lumps of cells called polyps from growing in the lining of the colon and small intestines. The team then noticed that feeding the rodents a diet low in sugar and starch also reduced the growth of polyps.

The mice had two gene mutations often linked to colon cancer in people,one of which derails a cell’s ability to fix errors that arise during DNA replication, known as the mismatch DNA repair system.

A mismatch repair deficiency causes cells in the lining of the colon to divide quickly, explains study leader Alberto Martin, an immunologist at the University of Toronto. Bacteria and carbs speed the process, he says, damaging the genome and leading to tumor growth.

The researchers surmised that when microbes feast on carbohydrates, the germs must produce a chemical that pushes colon cells lacking the ability to repair DNA mismatches toward uncontrollably multiplying into tumors.

The researchers discovered that gut bacteria process carbohydrates into butyrate, which can induce cancer in  APCMin/+MSH2−/− mice by allowing cancerous  MSH2−/−cells to proliferate uncontrollably in the colon.

02.26.2013

cavemen had fewer cavities

The teeth of this Egyptian skull are healthier than the teeth of most people living today.

Science magazine reports on pre-historic dental hygiene. Compared to modern mouths, the mouth’s of cavemen seem to have been colonized by fewer bacteria that cause tooth decay. The switch to agriculture and a diet that includes lots of sugars and refined carbohydrated seem to correspond to a surge in these types of bacterial species:

With these data, they charted the spectrum of bacterial species within the human mouth over the past 7500 years. Hunter-gatherers had fewer species that cause cavities and periodontal disease, and different percentages of all 15 phyla of bacteria found in modern teeth, plus some unclassified bacteria. Early farmers showed a sharp increase in bacteria that cause tooth decay, such as a Veillonellaceae strain, and a dramatic surge inPorphyromonas gingivalis, which causes periodontal disease.

The first significant sample of S. mutans turned up around 4300 years ago in the Bronze Age in Yorkshire, U.K. Overall bacterial diversity, including higher levels of S. mutans and P. gingivalis, seemed to stabilize through the Bronze Age and medieval period. Then, sometime in the past 400 years, the diversity of bacteria within each tooth dropped sharply once again. Modern samples and preliminary data from the mid-19th century show an oral environment even more dominated by S. mutans. Cooper concludes that the change occurred with the Industrial Revolution, about 1850 in England, when cavities also increased and refined sugars entered the diet. “Sugar and flour caused everything to go berserk,” he says.

More here and here.

01.24.2013

dogs, wolves and carbs

Domesticated dog breeds evolved long ago from the wolf. In a study published in Nature, researchers examined differences in the genomes of modern domesticated breeds and wolves and made some interesting discoveries. They expected differences in the nervous systems since the species behave differently. They also found many differences in genes effecting metabolism, especially digestion of carbohydrates. Domesticated breeds digest starches much better than wolves.  From Science News:

The new study focuses on genetic differences between 60 dogs representing 14 breeds and 12 wolves from around the world. Those changes, the researchers reasoned, could identify genes that were important in separating dogs from wolves.

The researchers determined the genetic makeup of groups of dogs and compared the results to those from wolves, concentrating on parts of the genetic instruction book that differ between the two species. As they had expected, the researchers uncovered differences in many genes relating to the brain. But the search also revealed lots of genes involved in starch digestion and metabolism, and in the use of fats. Dogs, the team found, have more copies than wolves do of the AMY2B gene, which produces an enzyme that breaks starch into easily digestible sugars.

Other genetic variants seem to contribute to dogs’ increased ability to convert a sugar called maltose to glucose, the sugar that cells prefer to burn for energy. Yet other genetic changes improve dogs’ ability to move glucose into their cells. Combined, the tweaks alter dogs’ metabolism so they can get more energy out of a carbohydrate-rich diet than wolves can, the researchers conclude. The scientists confirmed the effect of the genetic variants by identifying biochemical differences in starch metabolism in blood and tissue samples from dogs and wolves.

//madurird.com/4/4535925