Category: News (page 2 of 17)

sperm counts are falling

sperm egg fertilization

Some studies  show declining sperm counts in many Western societies. Is humanity doomed?

Continuing our recent exploration of human fertility, Julia Belluz atVox reports on the continued decline in human sperm counts.

In 2017, Hagai Levine et al.  published a meta-analysis in Human Reproduction Update detailing how sperm counts were halved between the 1970s and 2011 in North America, Europe, Australia and New Zealand. Since then, there has been lots of hand-wringing about what the results mean for the future of human fertility and reproduction. After talking wtih epidemiologists and men’s health professionals, Julia breaks down what these observed trends might mean.

First even though sperm counts have declined they are still within in normal range. The observed decrease was from 60 million to 30 million sperm per mL of ejaculate. To be in the normal range, counts should be above 15 million/mL.

Continuing on, she points out the limited scope of the problem. The decline only seemed apparent in Western countries:

The study authors also found the slope of the sperm count decline wasn’t as significant in the non-Western countries (in South America, Asia, and Africa), where sperm count even went up among men who were known to have fathered a child. (They thought this may be because men in non-Western countries haven’t been exposed to the same chemicals from industrial development as Western men have; more on that later.) But this raises the question of whether there’s something else that’s different about the groups or studies that might explain this variation.

And there is always the possibility of confounding variables in meta-analyses like this where experiments from over many decades and in many different countries are analyzed to discern a pattern. Male doctors that she was able to speak with have not noticed a decline that would correlate with what was observed in the publication.

Read Julia’s artcle here to get the rest of the details. And she ends with some tips for enhancing sperm quality, for if and when you are trying to conceive.

airport trays are full of germs

airport tray germs

Trays at airport security stations are loaded with microbes. A new study shows they can contain more viruses than toilets.

Air travel is a well known culprit in the spread of infectious diseases, such as the common cold and the flu. We can now add another potential mechanism for the spread of these types of infections, thanks to a new study published in BMC Infection Diseases last month.

Scientists from the University of Nottingham in England and the Finnish National Institute for Health and Welfare swabbed the trays and other airport surfaces after peak travel times, then identified traces of common respiratory viruses that were found in those samples. They looked at a variety of surfaces including toilets, pay machines, hand rails and luggage trays. Of all of the surfaces that they sampled, the luggage trays contained the most identifiable traces of respiratory viruses. Out of the 8 tray samples, 4 of them were positive for respiratory viruses like rhinovirus, which causes the common cold, and influenza, or the flu. Out of the 14 samples from the toilet flush button, zero gave positive results.

We know that objects that are frequently handled or manipulated with our hands tend to be laden with bacteria. Mobile phones, tv remotes and computer keyboards have been identified as having high bacterial counts. It now appears that the same applies to airport trays.

One caveat of the study is that although traces of viral DNA were found on various surfaces, this does not necessarily mean that they were contagious or able to infect humans. However, viruses and microbes have been known to survive for a few days on surfaces.

What can you do to minimize your risk of infection? The best advice still applies:  Wash your hands!

the problem with cancer cells

HeLa cells cancer research

HeLa cells, cancer cells originally isolated from Henerietta Lacks, are among the most widely used cell lines for scientific research

Cell lines are frequently used in cancer research studies. They are pretty easy to maintain and they grow fast. The cell lines give us insight into some of the cellular pathways involved in tumor biology. They are often used as early-stage screens for potential cancer therapeutics, even though scientists know that they do not exactly share the same biology as an actual tumor. Cancer cells grow rapidly and they generate many mutations in the process. In a few cycles, the cells that you have in culture are different genomically than the cells that you started with. But still, having some information on what cells maybe doing in a tumor is better than no information at all.

Now Derek Lowe calls attention to a new study in Nature, which points out a potential problem with these cell lines in culture. In this new paper, the researchers found that not only are cancer cells different from the tumor that they started from, but there can be many differences within a strains of any given cell line.  When they observed 27 strains of the MCF7 breast cancer line, the discovered rapid genetic diversification. They then looked at 13 additional cell lines and saw similar results. The genetic differences changed activation of gene expression, cell morphology and cell proliferation.

Derek Lowe sums up what this means for compound screening in cancer cell lines:

At least 75% of the compounds that showed strong inhibition of one MCF7 line were totally inactive against others. That’s going to confound experiments big-time, and this paper is a loud warning for people to be aware of this problem and to do something about it.

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